Blog Post

SKIN AGES WHEN THE MAIN CELLS IN THE DERMIS LOSE THEIR IDENTITY AND FUNCTION

  • By Center for Genomic Regulation
  • 01 Feb, 2019

With age, our tissues lose their function and capacity to regenerate after being damaged. A study published today in Cell by scientists at the Institute for Research in Biomedicine (IRB Barcelona) and the Centro Nacional de Análisis Genómico of the Center for Genomic Regulation (CNAG-CRG) explains how dermal fibroblasts age.

The main conclusion drawn is that these fibroblasts lose their cell identity, as if they had "forgotten" what they are, and consequently their activity is altered, thus affecting tissue. The study reveals the cellular and molecular pathways affected by ageing and proposes that they could be manipulated to delay or even reverse the skin ageing process.

The skin

Dermal fibroblasts are key for the production of collagen and other proteins that make up the dermis and that preserve the skin's function as a barrier. The activity of these cells is also crucial for the repair of skin damage. As we age, the dermis loses its capacity to produce collagen, and consequently its capacity to repair wounds is also significantly impaired.

"The elderly face many problems in this regard because their skin does not heal properly and its barrier properties are decreased, thus increasing the risk of skin infections and systemic infections," explains Salvador Aznar Benitah, ICREA researcher at IRB Barcelona and leader of the study. "The notion that the loss of cell identity is one of the underlying causes of ageing is interesting and one that we believe hasn't been considered before," he concludes.

Holger Heyn, team leader at the CNAG-CRG and co-leader of the study, explains that "cutting-edge technologies allow molecular analysis of individual cells. In this study, we have applied advanced techniques to obtain high resolution images of fibroblasts as they age."

First-authored by IRB Barcelona PhD student Marion Salzer, the study demonstrates that, during ageing, skin fibroblasts start to acquire many traits that are characteristic of adipocytes (fat cells). "This leads to them losing their cell identify and they also stop producing and secreting collagen like they should," explains Salzer.

The single-cell analysis confirmed the loss of fibroblast identity in aged animals. Using sophisticated computational tools, the scientists observed that aged fibroblasts show a less defined molecular conformation compared to young fibroblasts and that "they resemble the undefined cell states observed in newborn animals," says Heyn.

Although being basic research, Aznar Benitah comments that "this new knowledge might not only have cosmetic applications, for example anti-aging skin treatment, but more importantly, also therapeutic applications aiming to help aged skin to form scar tissue faster and more efficiently after being damaged or after an operation."


Journal Reference:

  1. Marion Claudia Salzer, Atefeh Lafzi, Antoni Berenguer-Llergo, Catrin Youssif, Andrés Castellanos, Guiomar Solanas, Francisca Oliveira Peixoto, Camille Stephan-Otto Attolini, Neus Prats, Mònica Aguilera, Juan Martín-Caballero, Holger Heyn, Salvador Aznar Benitah. Identity Noise and Adipogenic Traits Characterize Dermal Fibroblast Aging. Cell, 2018; DOI: 10.1016/j.cell.2018.10.012
By Editor February 15, 2019
History of LED Therapy  In 1903, a Nobel Prize of Medicine was given to a scientist by the name of Niels Finsen for the use of light therapy; once known as photo therapy. Research progressed and by the 1960s photo therapy – now referred to as LED Therapy (or LEDT) was being used primarily in Eastern Europe for treatment of chronic pain, arthritis and associated conditions, joint rehabilitation, and soft-tissue injury along with other medical ailments. During this same time LEDT was being used in a small sector of the United States by equestrian practices for animals with joint and soft tissue injury.
By Editor February 15, 2019

  • Myth #1: All Sun Must be Shunned

Getting safe sun exposure every day is actually one of the   best   actions you can take for your health, as this is how your body produces enough essential vitamin D, which is known to protect against cancer (including melanoma) and support your immune system, cardiovascular system, kidney function, bones and teeth, muscle strength and much more.  

While excessive sun exposure, such as getting sunburned, can certainly damage your skin,   sensible   sun exposure is not only quite healthy, it's a fundamental step in reaching optimal health.  

The skin around your eyes and your face is typically much thinner than other areas on your body and is a relatively small surface area so will not contribute much to vitamin D production. So it is strongly recommended that you protect this fragile area of your body, as it is at a much higher risk for cosmetic photo damage and premature wrinkling. You can use a safe sunblock in this area or wear a cap that always keeps your eyes in the shade.  

  • Myth #2: Tanning Must be Avoided

Assuming you use sensible exposure and avoid getting burned, sensible tanning the "old-fashioned" way (i.e. out in the sun) is perfectly acceptable. The first few days, you should limit your exposure to the sun to allow your body's melanocyte cells to rev up the ability to produce protective pigmentation that not only gives you a tan, but also serves to help protect you against overexposure to the sun.  

If you are a fairly light-skinned individual that tends to burn, you will want to limit your initial exposure to a few minutes, especially if it is in the middle of summer.  

The more tanned your skin will get, and/or the more tanned you want to become, the longer you can stay in the sun. If it is early or late in the season and/or you are a dark-skinned individual, you could likely safely have 30 minutes on your initial exposure. If you are deeply pigmented and your immediate ancestors are from Africa, India or the Middle East, it is possible you may not even have to worry about how long you are exposed.

Always err on the side of caution however, and let it be your primary goal to never get sun burned, while also protecting the sensitive skin around your eyes and face, as noted above.

  • Myth #3: Sunless Tanning Lotions/Sprays are Safe

Sunless tanners contain a lengthy list of chemical agents — up to 45 in the case of spray tanners. Many of these agents have never been studied for their long-term effects on human health, because the U.S. Food and Drug Administration does not systematically review the safety of personal care products.  

One of the main ingredients in spray tanning solutions is dihydroxyacetone, a color additive that darkens your skin by reacting with amino acids in your skin's surface layer. Dihydroxyacetone is often abbreviated DHA (which should not be confused with docosahexaenoic acid, the healthy omega-3 fat often given the same abbreviation).  

Manufacturers of sunless tanning products claim DHA is a simple carbohydrate sugar solution, but some toxicologists disagree. Part of the problem is that the U.S. government's regulations for DHA allow contaminants such as lead, arsenic and mercury. Further, a report by the National Toxicology Program 1   suggests the risks of DHA remain unclear, pointing to some evidence that DHA may be a mutagen that could induce breaks in DNA strands, which could contribute to accelerated aging and even skin cancer.  

  • Myth #4: The Higher the SPF of Your Sunscreen, The Better

It's generally unnecessary to purchase sunscreen with a sun protection factor (SPF) greater than 50. The reason for this is because while SPF works by absorbing, reflecting or scattering the sun's rays on your skin, its protective ability is not linear and does not offer a great deal more protection at higher levels.  

With regards to SPF, another important factor to remember is that SPF only protects against UVB rays, which are the rays within the ultraviolet spectrum that allows your body to produce vitamin D in your skin. But the most dangerous rays, in terms of causing skin damage and cancer are the   UVA rays. This is why you always want to make sure any sunscreen you buy protects against UVA's as well as UVB's … and does NOT contain any   common toxic ingredients , such as oxybenzone or retinyl palmitate.  

Myth #5: All Skin Care Products on the Market are Safe

It is important to understand that of the 10,500 ingredients used in your personal care products, fewer than 20 percent have been reviewed for safety in the last 30 years, according to an Environmental Working Group (EWG) analysis. 2

The reviews that have been done were conducted by a fox in the henhouse—the Cosmetics Ingredients Review, which is run by the cosmetics industry! Not all ingredients need even be mentioned on the label—if they don't want to include one for some reason, they can just leave it off. Therefore, most personal care product formulations are based on nothing more than marketing success, designed to smell good, look good and feel good when you rub them on your skin, regardless of their impact on your health.

But in reality, as the CNN video above describes, many skin care products on the market contain chemicals (including parabens, phthalates, triclosan and others) that have been linked to cancer, hormone disruption, reproductive toxicity and other health problems.

One of the core principles to remember when it comes to skin care is that whatever you slather onto your skin will be absorbed into your body and enter your bloodstream. This is why it's so important to avoid skin care products containing questionable chemicals! Your skin is an   excellent   drug delivery system, so you should be just as careful with what you put on your skin as you are with what you eat, if not more so, as your gut actually helps protect you against some of the toxins you ingest by filtering them out ... a protection you don't get when a chemical is absorbed through your skin.



By Editor February 9, 2019
You’ve probably read or heard the expression “fine lines and wrinkles” more than once when it comes to anti-ageing skin care. But do you know the difference between the two? Or what causes them? Or how you can prevent them in the first place? If you answered “no” to any of those questions, keep reading this post.
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When it comes to men’s beauty routines, our focus is usually on general hygiene and grooming. If we’re being honest, anti-ageing tips for men tend to go unaddressed. But just like male hair loss and baldness, skin ageing is something many men are genuinely concerned about - even if they don’t say it out loud.
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By Source: Laseraway.com January 14, 2019

Ever wonder how women in ancient times or in the Renaissance used to make themselves beautiful? 

Well, let’s just say they didn’t have the skincare wonders we have now – med spa procedures,  Botox , and countless anti-aging creams and serums. 

Curious to learn more about the history of skin care? Then travel back through time with us as we discuss how women in ancient cultures up to modern day cared for their skin.

HOW DID PEOPLE LOOK HOT CENTURIES AGO?

Ancient Egypt

Did you know that the first archaeological evidence of cosmetics is from Ancient Egypt roughly 6,000 years ago? But cosmetics weren’t just for aesthetics – they also protected the Ancient Egyptians from the elements, like the sun and insects. Makeup was also used to honor gods and goddesses. In terms of skincare, the Ancient Egyptians used castor, sesame, and moringa oils to fight wrinkles and preserve their youth. Ancient Egyptians also made a soap paste out of clay and olive oil to cleanse their skin. What is more, Egyptian women incorporated honey and milk masks into their beauty regimes to moisturize their skin, and they also took milk baths and used dead sea salts to exfoliate, rejuvenate, and heal their skin.

Ancient Greeks

In Ancient Greece, precious oils, perfumes, cosmetic powders, eye shadows, skin glosses, paints, beauty unguents, and hair dyes were in universal use. Ancient Greeks made their own skincare products using local, natural ingredients. One of the most widely used skincare treatments was mixing fresh berries with milk, and then applying the paste on the facial area. The Ancient Greeks also used olives and olive oil as exfoliants and moisturizers. Lastly, honey along with milk and yogurt were used as anti-aging preparations.

Medieval Times

During the 12th century, cosmetics were regularly used in medieval Europe. Ointments consisted of animal fats. Smooth, white skin was highly regarded, and many women used herbal remedies to promote fair skin and diminish pimples. Aloe vera, rosemary, and cucumbers were used to cleanse the skin. Seeds, leaves, and flowers were also mixed with honey to create face masks, and vinegar was used as an astringent.

Renaissance

Women in the Renaissance period used silver mercury, lead, and chalk to color their faces. Most of the skin care practices were the same as the medieval period, and women primarily relied on herbs and honey to cleanse and rejuvenate their skin. Some other skin care remedies included using broom stalks to cleanse the skin and oatmeal boiled in vinegar to treat pimples. Bread soaked in rose water was also used to soothe puffy eyes.

The Baroque Era

During the Baroque Era, women believed in saunas and sweat cleansing. Milk baths were also used for smoother, clearer skin. Make up during this time was intended to look like paint, and heavy makeup was considered more respectable. Rouge was very popular, and in the 1780s, French women used two million pots of rogue per year. Women’s lips were reddened with distilled alcohol or vinegar.

1800s

Exercise, cleanliness, and skincare were all held in high regard during the 1800s. Zinc oxide was used to lighten skin, but often caused allergic reactions. Hygiene products became less expensive and more accessible. Harsh cleansers were often used as were egg yolks, honey and oatmeal to often the skin and help diminish blemishes. Lemon juice was also used to naturally bleach the skin a few shades lighter. During this time, too, Chapstick, Vaseline, and baby powder were invented, all of which were used in skincare regimes.

1900s

The 1900s was an explosion in terms of accessible skincare for women. Carmex was invented in 1937, and sunscreen in 1944. In 1946, Estee Lauder launched their cosmetics line in NYC, and then in the 1950s Clearasil, Ponds, Oil of Olay, and Clinique were all launched, too. The 1980s saw a rise in all natural  skincare  products. Dr. Howard Murad’s line was launched in 1989, and Burt’s Bees in the 1980s, too. In 2002, the FDA approved Botox for frown lines on the face. In 2007, The Zeno, a hand-held, battery-operated device, transfers heat onto a blemish, killing the bacteria and making them disappear after only a few treatments.


    Reference:

    https://www.laseraway.com/news/brief-history-skincare-ages/
    By Editor December 18, 2018

    Studies have shownthat eating foods with these deeply colored pigments can make your face actually look healthier than being tanned. [1]

    The more red and yellow tones found in your skin, the more attractive the people were found to be. The redder tones are caused when people are flushed with blood, particularly if the blood has lots of oxygen in it. Researchers found that, given the choice between skin color caused by suntan and skin color caused by carotenoids, people preferred the carotenoid skin color, so if you want a healthier and more attractive skin color, you are better off eating a healthy diet.

    In order to have clear, healthy skin, you need to make sure your body is relatively free of toxins, so cleansing your body of dangerous substances while putting in the finest nutrients is essential.  The organs responsible for providing you with beautiful skin include your liver, kidneys, adrenals, thyroid, and your large and small intestines. 

    • Your liver and kidneys  are the two organs that filter out impurities on an ongoing basis. If your diet is less than ideal, these two organs can easily become overtaxed, which can lead to breakouts and other skin problems. 
    • Your adrenals  make many essential hormones, such as pregnenolone, DHEA, estrogen,  progesterone  and testosterone. Hormonal imbalances can also result in problematic skin conditions, so adrenal function is important as well. 
    • A well-nourished, energetic  thyroid  also provides hormones and works closely with your adrenals to create energy. Dry, flakey, sluggish skin can be evidence of a weak thyroid. 
    • Your small- and large intestines  provide nutrients to all your organs and remove waste products from your body. When waste meant for elimination remains in your intestines your skin becomes thick, oily and blemished. Pure, flawless skin is typically a reflection of clean intestines. 

    Eating a healthy diet as described in my  nutrition plan , which focuses on whole, bioavailable organic foods, is your number one strategy for helping your body detox naturally while supplying the necessary nutrients your skin needs to thrive. That said, some foods are particularly effective at promoting beautiful, clear skin, including:

    • Animal-based omega-3 fats:  Omega-3 fats help to normalize skin lipids and prevent dehydration in the cells. This keeps skin cells strong and full of moisture, which can help to decrease the appearance of fine lines. Fatty acid deficiency can manifest in a variety of ways, but skin problems such as eczema, thick patches of skin, and cracked heels are common. Plus, omega-3 fats may have an anti-inflammatory effect that can help to calm irritated skin, giving you a clear, smooth complexion.
    • Vegetables:  Ideally fresh, organic and locally grown.
    • Fermented foods  are even better as they can start with the same vegetables but are converted by bacteria to superfoods, which help promote the growth of friendly intestinal bacteria and aid in digestion. 
    • Avoid  Sugars, Fructose and Grains:  This is probably the single most important step you can take to improve your skin health. If you eliminate all sugars, fructose and grains from your diet for a few weeks there is a major likelihood you will notice rapid improvement in your complexion.


    Reference:
    [1]  Evolution and Human Behavior Volume 32, Issue 3, May 2011, Pages 216–227
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